Serum apolipoprotein b-48 concentration is associated with a reduced estimated glomerular filtration rate and increased proteinuria

Aim: apolipoprotein b-48 (apob-48) is a constituent of chylomicrons and their remnants (chylomicron remnants). a high concentration of serum apob-48 is suspected to be a major risk factor for the development of atherosclerotic cardiovascular disease. proteinuria and a reduced estimated glomerular filtration rate (egfr) are independent risk factors for cardiovascular events and renal dysfunction. in the present study,we examined whether the serum apob-48 concentration is associated with renal dysfunction.methods: a total of 264 patients was enrolled and classified into four groups according to the egfr and level of proteinuria: a high egfr (＞60 ml/min/1.73 m2) without proteinuria (≥1＋ by urine dipstick) (n = 50); a high egfr with proteinuria (n = 75); a low egfr (＞60 ml/min/1.73 m2) without proteinuria (n = 74); and a low egfr with proteinuria (n = 65). biochemical markers of lipid metabolism,including the fasting serum apob-48 concentration,were compared between the four groups.results: the serum log-apob-48 and log-apob-48/tg levels were significantly higher in the patients with a high egfr with proteinuria,low egfr with proteinuria and low egfr without proteinuria than in those with a high egfr without proteinuria,with the most significant differences for these parameters. the egfr was found to be significantly correlated with the log-apob-48 and log-apob-48/tg levels,whereas urinary protein was found to be significantly correlated with the log-apob-48 level only. a multiple regression analysis indicated that the log-apob-48/tg level was a significant determinant of a reduced egfr.conclusions: both a low egfr (＜60) and proteinuria (≥1＋) are independent determinants of a high apob-48 concentration. taken together,the present results suggest that an increased serum apob-48 concentration contributes to an increased risk of cardiovascular events. © 2014,japan atherosclerosis society. all rights reserved.