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MicroRNAs and lipoprotein metabolism
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نویسنده
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horie t. ,baba o. ,kuwabara y. ,yokode m. ,kita t. ,kimura t. ,ono k.
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منبع
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journal of atherosclerosis and thrombosis - 2014 - دوره : 21 - شماره : 1 - صفحه:17 -22
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چکیده
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Micrornas (mirnas; mirs) are small,non-protein-coding rnas that negatively regulate the gene expression. they bind to specific mrnas and inhibit translation or promote mrna degradation. recently,some mirnas have been shown to be involved in lipid homoeostasis. in particular,mir- 122 and mir-33 have a significant impact on lipid homeostasis and are potential therapeutic targets for treating lipid disorders and/or atherosclerosis. in this review,we describe the current understanding of the function of mirnas in lipid homeostasis,with a focus on lipoprotein metabolism.
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کلیدواژه
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Atherosclerosis; HDL-C; MicroRNA
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آدرس
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department of cardiovascular medicine,graduate school of medicine,kyoto university,kyoto,japan,department of clinical innovative medicine,institute for advancement of clinical and translational science,graduate school of medicine,kyoto university,kyoto, Japan, department of cardiovascular medicine,graduate school of medicine,kyoto university,kyoto, Japan, department of cardiovascular medicine,graduate school of medicine,kyoto university,kyoto, Japan, department of clinical innovative medicine,institute for advancement of clinical and translational science,graduate school of medicine,kyoto university,kyoto, Japan, department of cardiovascular medicine,kobe city medical center general hospital,kobe, Japan, department of cardiovascular medicine,graduate school of medicine,kyoto university,kyoto, Japan, department of cardiovascular medicine,graduate school of medicine,kyoto university,kyoto, Japan
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Authors
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