Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world

Background. since taurine (t) administration was proven to decrease blood pressure (bp) and stroke mortality in stroke-prone spontaneously hypertension rates (shrsp) in the 1980s and our who-coordinated cardiac (cardiovascular diseases and alimentary comparison) study demonstrated that among 5 diet-related factors,namely total cholesterol (t-cho),body mass index (bmi),sodium (na),magnesium (m),and t to creatinine (cr) ratio in 24-hour urine (24u),both t/cr and m/cr were inversely related to coronary heart disease mortalities in males and females and t/cr was inversely related to stroke mortalities in males and females. we further analyzed the associations of individual t/cr and m/cr levels to cardiovascular risks in the present study. method. from who-cardiac study populations,61 populations of 25 countries in the world,japanese populations with obviously higher 24u t excretion because of their common fish eating custom and the other populations in which both data of t and m were not available were excluded and the data of 3960 individuals from 41 who-cardiac study populations were used for the following analyses. results. the means of 24u t/cr and m/cr ratios in total individual data were 639.4 and 82.8,respectively. the average of bmi,systolic and diastolic blood pressure (sbp,dbp),t-cho and atherogenic index (ai) in the individuals with more than the means of t/cr or m/cr were significantly lower than those of individuals with less than the means. the cardiac study participants were divided into the following 4 groups by these means: a (t/cr and m/cr mean),b (t/cr mean,m/cr < mean),c (t/cr < mean,m/cr mean),d (t/cr and m/cr < mean). the group a showed significantly lower values compared with the group d in bmi,sbp,dbp,t-cho,and ai. conclusions. cardiovascular risks were proven to be highly significantly lower in individuals who were excreting both 24u t and m,more than the averages despite differences in ethnicity and genetic background. since t and m are biomarkers for seafood,vegetables,soy,nuts,milk,etc.,dietary custom to eat these food sources could be recommended for cardiovascular disease prevention. © 2010 yamori et al; licensee biomed central ltd.