Association between transforming growth factor 1 polymorphisms and atrial fibrillation in essential hypertensive subjects

Background. the association of tgf 1 polymorphisms and atrial fibrillation (af) in essential hypertensive (eh) subjects remains unknown. methods eh subjects with af (eh+af+) and sinus rhythm (eh+af-) were enrolled. the polymorphisms of +869 t c at codon 10 and + 915 g c at codon 25,were genotyped. the clinical characteristics including serum tgf 1 levels were detected. results. the gg genotypes of tgf 1 +915 g c at codon 25 were more prevalent in subjects from eh+af+ group than those from eh+af- group (p = 0.009). the subjects with gg genotype from eh+af+ group had the highest mean serum tgf 1 level,which was significantly higher than that of gg genotype subjects from eh+af- group (3.18 0.24 ng/dl vs.2.29 0.14 ng/dl,p < 0.05). multiple analyses revealed that the tgf 1 gg genotype of +915 g c at codon 25 presented a 3.09 times higher risk in developing af in the multivariate model after adjusting for age and gender. conclusion. the polymorphisms of tgf 1 +915 g c at codon 25 were associated with occurrence of af and serum tgf 1 level in eh subjects. © 2010 wang et al; licensee biomed central ltd.