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Roles of planar cell polarity pathways in the development of neutral tube defects
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نویسنده
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wu g. ,huang x. ,hua y. ,mu d.
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منبع
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journal of biomedical science - 2011 - دوره : 18 - شماره : 1
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چکیده
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Neural tube defects (ntds) are the second most common birth defect in humans. despite many advances in the understanding of ntds and the identification of many genes related to ntds,the fundamental etiology for the majority of cases of ntds remains unclear. planar cell polarity (pcp) signaling pathway,which is important for polarized cell movement (such as cell migration) and organ morphogenesis through the activation of cytoskeletal pathways,has been shown to play multiple roles during neural tube closure. the disrupted function of pcp pathway is connected with some ntds. here,we summarize our current understanding of how pcp factors affect the pathogenesis of ntds. © 2011 wu et al; licensee biomed central ltd.
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کلیدواژه
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Neural tube defects; organ morphogenesis; planar cell polarity; signaling pathway
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آدرس
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department of pediatrics,west china second university hospital,sichuan university,chengdu,sichuan 610041,china,department of biomedical science,college of medicine,florida atlantic university,boca raton,fl 33431, United States, department of biomedical science,college of medicine,florida atlantic university,boca raton,fl 33431, United States, department of pediatrics,west china second university hospital,sichuan university,chengdu,sichuan 610041, China, department of pediatrics,west china second university hospital,sichuan university,chengdu,sichuan 610041,china,department of neurology,newborn brain research institute,university of california,san francisco,ca 94143, United States
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Authors
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