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Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
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نویسنده
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vasquez e.c. ,peotta v.a. ,gava a.l. ,pereira t.m.c. ,meyrelles s.s.
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منبع
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journal of biomedical science - 2012 - دوره : 19 - شماره : 1
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چکیده
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Cardiovascular death is frequently associated with atherosclerosis,a chronic multifactorial disease and a leading cause of death worldwide. genetically engineered mouse models have proven useful for the study of the mechanisms underlying cardiovascular diseases. the apolipoprotein e-deficient mouse has been the most widely used animal model of atherosclerosis because it rapidly develops severe hypercholesterolemia and spontaneous atherosclerotic lesions similar to those observed in humans. in this review,we provide an overview of the cardiac and vascular phenotypes and discuss the interplay among nitric oxide,reactive oxygen species,aging and diet in the impairment of cardiovascular function in this mouse model. © 2012 vasquez et al; licensee biomed central ltd.
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کلیدواژه
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atherosclerosis; cardiac function; Hypercholesterolemia; mouse; vascular senescence
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آدرس
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department of physiological sciences,health sciences center,federal university of espirito santo,vitoria,es,brazil,emescam school of health sciences,vitoria,es, Brazil, university of iowa,iowa city,ia, United States, department of physiological sciences,health sciences center,federal university of espirito santo,vitoria,es,brazil,biotechnology graduate program,health sciences center,federal university of espirito santo,vitoria,es, Brazil, federal institute of education,science and technology (ifes),vila velha,es, Brazil, department of physiological sciences,health sciences center,federal university of espirito santo,vitoria,es, Brazil
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Authors
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