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Dysregulation of MicroRNAs in cancer
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نویسنده
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chen p.-s. ,su j.-l. ,hung m.-c.
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منبع
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journal of biomedical science - 2012 - دوره : 19 - شماره : 1
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چکیده
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Micrornas (mirnas) are involved in multiple biological activities as well as disease progression including cancer. interestingly,mirnas could act as either tumor suppressors or oncogenes depending on the functions of their targets. using high-throughput profiling,dysregulation of mirnas has been widely observed in different stages of cancer,and there is mounting evidence demonstrating several misguided mechanisms that cause mirna dysregulation. in this review,we summarize the key functions of mirnas in cancer,especially those affecting tumor metastasis and drug resistance. moreover,the mechanisms leading to dysregulation of mirnas,including genomic abnormalities,dna/histone modifications,transcriptional regulation,abnormal biogenesis,and interaction between mirnas,are also discussed. © 2012 chen et al.; licensee biomed central ltd.
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کلیدواژه
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Cancer progression; miRNA biogenesis; miRNA dysregulation
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آدرس
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department of medical laboratory science and biotechnology,national cheng kung university,tainan,taiwan,institute of basic medical sciences,national cheng kung university,tainan,taiwan,center for molecular medicine,china medical university hospital,taichung, Taiwan, graduate institute of cancer biology,china medical university,taichung,taiwan,department of biotechnology,asia university,taichung,taiwan,center for molecular medicine,china medical university hospital,taichung, Taiwan, center for molecular medicine,china medical university hospital,taichung,taiwan,department of molecular and cellular oncology,university of texas,md anderson cancer center,houston,tx, United States
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Authors
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