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Hypoxia-regulated target genes implicated in tumor metastasis
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نویسنده
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tsai y.-p. ,wu k.-j.
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منبع
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journal of biomedical science - 2012 - دوره : 19 - شماره : 1
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چکیده
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Hypoxia is an important microenvironmental factor that induces cancer metastasis. hypoxia/hypoxia-inducible factor-1α (hif-1α) regulates many important steps of the metastatic processes,especially epithelial-mesenchymal transition (emt) that is one of the crucial mechanisms to cause early stage of tumor metastasis. to have a better understanding of the mechanism of hypoxia-regulated metastasis,various hypoxia/hif-1α- regulated target genes are categorized into different classes including transcription factors,histone modifiers,enzymes,receptors,kinases,small gtpases,transporters,adhesion molecules,surface molecules,membrane proteins,and micrornas. different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. we hope that this review will provide a framework for further exploration of hypoxia/hif-1α- regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia. © 2012 tsai and wu; licensee biomed central ltd.
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کلیدواژه
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Epithelial-mesenchymal transition; Hypoxia; Hypoxia-inducible factor; Metastasis; Target genes
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آدرس
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institute of biochemistry and molecular biology,national yang-ming university,no.155,li-nong st.,sec.2,peitou,taipei 112, Taiwan, institute of biochemistry and molecular biology,national yang-ming university,no.155,li-nong st.,sec.2,peitou,taipei 112,taiwan,head and neck cancer research program,cancer research center,national yang-ming university,no.155,li-nong st.,sec.2,peitou,taipei 112,taiwan,genome research center,national yang-ming university,taipei 112, Taiwan
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Authors
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