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Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a
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نویسنده
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teruel r. ,martínez-martínez i. ,guerrero j.a. ,gonzález-conejero r. ,de la morena-barrio m.e. ,salloum-asfar s. ,arroyo a.b. ,águila s. ,garcía-barberá n. ,miñano a. ,vicente v. ,corral j. ,martínez c.
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منبع
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journal of biomedical science - 2013 - دوره : 20 - شماره : 1
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چکیده
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Background: developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin,the most relevant endogenous anticoagulant. results: in this study,we showed a significant reduction of sialic acid content in neonatal antithrombin compared with adult antithrombin in mice. mrna levels of st3gal3 and st3gal4,two sialyltransferases potentially involved in antithrombin sialylation,were 85% lower in neonates in comparison with adults. in silico analysis of mirnas overexpressed in neonates revealed that mir-200a might target these sialyltransferases. moreover,in vitro studies in murine primary hepatocytes sustain this potential control. conclusions: these data suggest that in addition to the direct protein regulation,micrornas may also modulate qualitative traits of selected proteins by an indirect control of post-translational processes. © 2013 teruel et al.; licensee bio med central ltd.
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کلیدواژه
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Antithrombin; Microarray; miRNAs; Post-natal development; Post-translational modifications; Sialytransferases
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آدرس
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centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain, centro regional de hemodonación,university of murcia,imib spain,c/ronda de garay s/n,30003 murcia, Spain
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Authors
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