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Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome
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نویسنده
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tsai j.-j. ,chokephaibulkit k. ,chen p.-c. ,liu l.-t. ,hsiao h.-m. ,lo y.-c. ,perng g.c.
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منبع
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journal of biomedical science - 2013 - دوره : 20 - شماره : 1
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چکیده
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Dengue is becoming recognized as one of the most important vector-borne human diseases. it is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding,making it an escalating global health problem of today. dengue presents with spectrum of clinical manifestations,ranging from asymptomatic,undifferentiated mild fever,dengue fever (df),to dengue hemorrhagic fever (dhf) with or without shock (dss),a life-threatening illness characterized by plasma leakage due to increased vascular permeability. currently,there are no antiviral modalities or vaccines available to treat and prevent dengue. supportive care with close monitoring is the standard clinical practice. the mechanisms leading to dhf/dss remains poorly understood. multiple factors have been attributed to the pathological mechanism,but only a couple of these hypotheses are popular in scientific circles. the current discussion focuses on underappreciated factors,temperature,natural igm,and endotoxin,which may be critical components playing roles in dengue pathogenesis. © 2013 tsai et al.; licensee biomed central ltd.
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کلیدواژه
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Dengue; DHF; DSS; Endotoxin; Fever; Flavivirus; Hemorrhagic
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آدرس
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tropical medicine center,kaohsiung medical university hospital,kaohsiung medical university,kaohsiung,taiwan,division of infectious diseases,department of internal medicine,kaohsiung medical university hospital,kaohsiung,taiwan,department of internal medicine,school of medicine,kaohsiung medical university,kaohsiung, Taiwan, department of pediatrics,faculty of medicine siriraj hospital,mahidol university,bangkok, Thailand, tropical medicine center,kaohsiung medical university hospital,kaohsiung medical university,kaohsiung,taiwan,department of laboratory medicine,kaohsiung medical university hospital,kaohsiung,taiwan,department of medical laboratory science and biotechnology,college of health sciences,kaohsiung medical university,kaohsiung, Taiwan, department of medical laboratory science and biotechnology,college of medicine and life science,chung-hwa university of medical technology,tainan, Taiwan, department of pathology and laboratory medicine,emory vaccine center,emory university school of medicine,atlanta,ga, United States, institute of bioinformatics and biosignal transduction,college of bioscience and biotechnology,national cheng kung university,tainan,taiwan,center of infectious disease and signaling research,national cheng kung university,tainan, Taiwan, department of pathology and laboratory medicine,emory vaccine center,emory university school of medicine,atlanta,ga,united states,center of infectious disease and signaling research,national cheng kung university,tainan,taiwan,department of microbiology and immunology,medical college,national cheng kung university,tainan, Taiwan
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Authors
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