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Escape from IFN-γ-dependent immunosurveillance in tumorigenesis
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نویسنده
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lin c.-f. ,lin c.-m. ,lee k.-y. ,wu s.-y. ,feng p.-h. ,chen k.-y. ,chuang h.-c. ,chen c.-l. ,wang y.-c. ,tseng p.-c. ,tsai t.-t.
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منبع
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journal of biomedical science - 2017 - دوره : 24 - شماره : 1 - صفحه:1 -9
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چکیده
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Immune interferon (ifn),also known as ifn-γ,promotes not only immunomodulation but also antimicrobial and anticancer activity. after ifn-γ binds to the complex of ifn-γ receptor (ifngr) 1-ifngr2 and subsequently activates its downstream signaling pathways,ifn-γ immediately causes transcriptional stimulation of a variety of genes that are principally involved in its biological activities. regarding ifn-γ-dependent immunosurveillance,ifn-γ can directly suppress tumorigenesis and infection and/or can modulate the immunological status in both cancer cells and infected cells. regarding the anticancer effects of ifn-γ,cancer cells develop strategies to escape from ifn-γ-dependent cancer immunosurveillance. immune evasion,including the recruitment of immunosuppressive cells,secretion of immunosuppressive factors,and suppression of cytotoxic t lymphocyte responses,is speculated to be elicited by the oncogenic microenvironment. all of these events effectively downregulate ifn-γ-expressing cells and ifn-γ production. in addition to these extrinsic pathways,cancer cells may develop cellular tolerance that manifests as hyporesponsiveness to ifn-γ stimulation. this review discusses the potential escape mechanisms from ifn-γ-dependent immunosurveillance in tumorigenesis. © 2017 the author(s).
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کلیدواژه
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Cancer; Escape; Hyporesponsiveness; IFN-γ; Immunosurveillance
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آدرس
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department of microbiology and immunology,school of medicine,college of medicine,taipei medical university,taipei 110,taiwan,graduate institute of medical sciences,college of medicine,taipei medical university,taipei 110, Taiwan, department of thoracic surgery,lotung poh-ai hospital,yilan 265, Taiwan, division of pulmonary medicine,department of internal medicine,shuang ho hospital,taipei medical university,taipei 110,taiwan,department of internal medicine,school of medicine,college of medicine,taipei medical university,taipei 110, Taiwan, department of internal medicine,school of medicine,college of medicine,taipei medical university,taipei 110,taiwan,graduate institute of toxicology,college of medicine,national taiwan university,taipei 100,taiwan,department of radiation oncology,wan fang hospital,taipei medical university,taipei 110,taiwan,department of biotechnology,hung kuang university,taichung 433, Taiwan, division of pulmonary medicine,department of internal medicine,shuang ho hospital,taipei medical university,taipei 110,taiwan,department of internal medicine,school of medicine,college of medicine,taipei medical university,taipei 110, Taiwan, division of pulmonary medicine,department of internal medicine,shuang ho hospital,taipei medical university,taipei 110,taiwan,department of internal medicine,school of medicine,college of medicine,taipei medical university,taipei 110,taiwan,graduate institute of clinical medicine,college of medicine,taipei medical university,taipei 110, Taiwan, school of respiratory therapy,college of medicine,taipei medical university,taipei 110, Taiwan, translational research center,taipei medical university,taipei 110, Taiwan, department of microbiology and immunology,school of medicine,college of medicine,taipei medical university,taipei 110, Taiwan, department of microbiology and immunology,school of medicine,college of medicine,taipei medical university,taipei 110, Taiwan, department of microbiology and immunology,school of medicine,college of medicine,taipei medical university,taipei 110, Taiwan
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Authors
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