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Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke
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نویسنده
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hsieh y.-c. ,hsieh f.-i. ,chen y.-r. ,hu c.-j. ,jeng j.-s. ,tang s.-c. ,chi n.-f. ,lin h.-j. ,lien l.-m. ,peng g.-s. ,chiou h.-y.
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منبع
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journal of biomedical science - 2017 - دوره : 24 - شماره : 1
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چکیده
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Background: estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. in this study,we analyzed the effect of a polygenic risk score (prs) constructed using inflammatory genes and estradiol levels on the risk of ischemic stroke. methods: this case-control study was conducted with 624 ischemic stroke patients and 624 age- and gender-matched controls. the prs estimated the polygenic contribution of inflammatory genes from ischemic stroke susceptibility loci. estradiol levels were measured using a radioimmunoassay. high and low estradiol levels were defined according to the log-transformed median estradiol levels in female and male controls. results: subjects in the fourth quartile of the prs had a significant 1.57-fold risk of ischemic stroke (95% confidence interval [ci],1.12 ~ 2.19),after adjusting for covariates compared to individuals in the lowest quartile. compared to individuals with high estradiol levels and a low prs as the reference group,those exposed to low estradiol levels and a high prs had an increased risk of ischemic stroke (odds ratio,3.35; 95% ci,1.79 ~ 6.28). similar results were also observed in males when the analysis was stratified by gender. conclusions: our data suggest that the prs can be useful in evaluating a high risk of ischemic stroke among patients,especially those exposed to low estradiol levels. © 2017 the author(s).
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کلیدواژه
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Estradiol; Inflammation; Ischemic stroke; Polygenic risk score
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آدرس
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program for neural regenerative medicine,college of medical science and technology,taipei medical university,taipei,taiwan,center for neurotrauma and neuroregeneration,taipei medical university,taipei,taiwan,program in biotechnology research and development,college of pharmacy,taipei medical university,taipe, Taiwan, school of public health,college of public health,taipei medical university,taipei, Taiwan, school of public health,college of public health,taipei medical university,taipei, Taiwan, department of neurology,taipei medical university shuang ho hospital,new taipei city,taiwan,department of neurology,school of medicine,college of medicine,taipei medical university,taipei,taiwan,cerebrovascular research center,taipei medical university,taipei, Taiwan, stroke center and department of neurology,national taiwan university hospital,taipei, Taiwan, stroke center and department of neurology,national taiwan university hospital,taipei, Taiwan, department of neurology,taipei medical university shuang ho hospital,new taipei city,taiwan,department of neurology,school of medicine,college of medicine,taipei medical university,taipei,taiwan,cerebrovascular research center,taipei medical university,taipei, Taiwan, department of emergency medicine,chi-mei medical center,tainan,taiwan,department of biotechnology,southern taiwan university of science and technology,tainan, Taiwan, department of neurology,shin kong wu ho-su memorial hospital,taipei,taiwan,school of medicine,college of medicine,taipei medical university,taipei, Taiwan, division of neurology,department of internal medicine,taipei veterans general hospital,hsinchu branch,hsinchu county, Taiwan, school of public health,college of public health,taipei medical university,taipei, Taiwan
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Authors
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