The association between cyclooxygenase-2 (COX-2/PTGS2) gene polymorphism and osteoarthritis [Siklooksijenaz-2 (COX-2/PTGS2) gen polimorfizmi ile osteoartrit arasindaki ilişki]

Objectives: this study aims to investigate the relationship between the risk for the development of osteoarthritis and cyclooxygenase-2 (cox 2) -765g>c gene polymorphism. patients and methods: we included a total of 100 osteoarthritis patients (18 males,82 females; mean age 60.4±8.4 years; range 41 to 81 years) who were treated in the physical therapy clinic and 100 healthy subjects without a history of arthritis (40 males,60 females; mean age 30.9±7.5 years; range 16 to 48 years) in our study between september 2006 and may 2008. the frequency of -765g>c gene polymorphism in the cox-2 promoter region was investigated in the osteoarthritis patients and the control group without a history of arthritis using the polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. the data were analysed with chi-square and logistic regression analysis. results: the frequencies of -765g>c polymorphism for gg,gc and cc genotypes were found to be 54%,35%,and 11% in the control group and 48%,34% and 18% in the osteoarthritis group,respectively. conclusion: based on the data obtained,it can be stated that there is no significant relation between cox-2 -765g>c polymorphism and osteoarthritis disease. furthermore,this study presents the first results of cox-2 promoter variant in turkish patients with osteoarthritis.