Is intraarticular administration of tranexamic acid efficient and safe as systemic administration in total knee arthroplasty? Single center,randomized,controlled trial [Total diz artroplastisinde eklem içi tranekzamik asit uygulamasi sistemik uygulama kadar etkin ve güvenilir midir? Tek merkez,randomize,kontrollü çalişma]

Objectives: this study aims to compare the efficiency and safety of intraarticular and intravenous tranexamic acid administration in patients who were performed primary total knee arthroplasty. patients and methods: this single center,randomized,controlled trial included 60 patients (8 males,52 females; mean age 67.8 years; range 53 to 87 years) who were performed primary total knee arthroplasty by three surgeons due to a diagnosis of primary osteoarthritis between january 2015 and june 2015. patients were separated into three groups. patients in group 1 and group 2 were administered 2 g intravenous tranexamic acid and 2 g intraarticular tranexamic acid,respectively. patients in group 3 were not administered tranexamic acid. pre- and postoperative hemoglobin difference,volume of blood collected in drains,and transfusion rate were analyzed. results: compared with the control group,there was no significant difference between group 1 and group 2 in terms of total blood loss from the drain,pre- and postoperative hemoglobin difference,and the need for blood transfusion. conclusion: both intraarticular and intravenous administrations reduce blood loss and need for transfusion and there is no significant difference between the two techniques in terms of safety.