نقش التهاب و استرس اکسیداتیو در سبب‌شناسی سندرم تخمدان پلی‌کیستیک: مطالعه مروری

ﻣﻘﺪﻣﻪ: در ﺳﺎل ﻫﺎی اﺧﯿﺮ ﻧﻘﺶ اﻟﺘﻬﺎب و اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ در ﺳﺒﺐ ﺷﻨﺎﺳﯽ ﺑﯿﻤﺎری ﺳﻨﺪرم ﺗﺨﻤﺪان ﭘﻠﯽ ﮐﯿﺴﺘﯿﮏ ﺑﯿﺶ از ﭘﯿﺶ ﻣﻮرد ﺗﻮﺟﻪ ﻗﺮار ﮔﺮﻓﺘﻪ اﺳﺖ. ﺑﺮرﺳﯽ ﻣﻄﺎﻟﻌﺎت ﻣﻮﺟﻮد در راﺑﻄﻪ ﺑﺎ اﺛﺮات واﺳﻄﻪ ﻫﺎی اﻟﺘﻬﺎﺑﯽ و اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ ﺑﺮ ﻋﻤﻠﮑﺮد ﺗﺨﻤﺪان در ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ pcos، ﺣﺎﮐﯽ از ﻧﻘﺶ ﮐﻠﯿﺪی اﯾﻦ ﻋﻮاﻣﻞ در ﭘﯿﺸﺮﻓﺖ و ﺗﻮﺳﻌﻪ ﻋﻮارض ﺑﯿﻤﺎری اﺳﺖ. ﻣﻄﺎﻟﻌﻪ ﻣﺮوری ﺣﺎﺿﺮ ﺑﺎ ﻫﺪف ﺟﻤﻊ ﺑﻨﺪی ﺣﻀﻮر و ﻧﻘﺶ واﺳﻄﻪ ﻫﺎی اﻟﺘﻬﺎﺑﯽ ﻣﺬﮐﻮر و ﻫﻤﭽﻨﯿﻦ ﺗﺄﺛﯿﺮ روﯾﮑﺮدﻫﺎی درﻣﺎﻧﯽ اﺧﯿﺮ ﺷﺎﻣﻞ اﺳﺘﻔﺎده از ﻣﮑﻤﻞ ﻫﺎی آﻧﺘﯽ اﮐﺴﯿﺪاﻧﯽ و ﻋﻮاﻣﻞ ﺿﺪاﻟﺘﻬﺎﺑﯽ در ﺑﻬﺒﻮد ﻧﺘﺎﯾﺞ ﭼﺮﺧﻪ ﻫﺎی درﻣﺎن ﻧﺎﺑﺎروری در اﯾﻦ ﺑﯿﻤﺎران اﻧﺠﺎم ﺷﺪ. روشﮐﺎر: در اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﻣﺮوری ﺟﻬﺖ ﯾﺎﻓﺘﻦ ﻣﻘﺎﻻت ﻣﺮﺗﺒﻂ، ﭘﺎﯾﮕﺎه ﻫﺎی اﻃﻼﻋﺎﺗﯽ science direct ،pubmed، scopus و google scholar ﺑﺎ اﺳﺘﻔﺎده از ﮐﻠﻤﺎت ﮐﻠﯿﺪی: ﺳﻨﺪرم ﺗﺨﻤﺪان ﭘﻠﯽ ﮐﯿﺴﺘﯿﮏ، اﻟﺘﻬﺎب، اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ، رادﯾﮑﺎل ﻫﺎی آزاد اﮐﺴﯿﮋن، ﻣﮑﻤﻞ ﻫﺎی آﻧﺘﯽ اﮐﺴﯿﺪاﻧﯽ، درﻣﺎن ﻧﺎﺑﺎروری، آﻧﺪروژن ﻫﺎ، ﺳﯿﺘﻮﮐﯿﻦ ﻫﺎ و ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ ﺑﺎ اﺳﺘﻔﺎده از ﻋﻤﻠﮕﺮﻫﺎی and و or از ژاﻧﻮﯾﻪ 1991 ﺗﺎ دﺳﺎﻣﺒﺮ 2020 ﻣﻮرد ﺟﺴﺘﺠﻮ ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﭘﺲ از ﺑﺮرﺳﯽ ﺗﻤﺎﻣﯽ ﻣﻘﺎﻻت در اﯾﻦ زﻣﯿﻨﻪ ﻣﺸﺨﺺ ﺷﺪ pcos ﺑﻪ ﻋﻨﻮان ﯾﮏ ﺑﯿﻤﺎری ژﻧﺘﯿﮑﯽ و ﺧﻮداﯾﻤﻨﯽ ﺑﺎ درﺟﺎﺗﯽ از اﻟﺘﻬﺎب ﻫﻤﺮاه اﺳﺖ ﮐﻪ ﻧﻘﺶ ﻣﻬﻤﯽ در ﺳﺒﺐ ﺷﻨﺎﺳﯽ، ﭘﯿﺸﺮﻓﺖ و ﺑﺮوز ﺑﯿﻤﺎری دارد. اﺧﺘﻼل در ﺗﺨﻤﮏ ﮔﺬاری ﺑﯿﻤﺎر، اﻓﺰاﯾﺶ ﻏﻠﻈﺖ رادﯾﮑﺎلﻫﺎی آزاد اﮐﺴﯿﮋن در ﺳﻠﻮلﻫﺎی ﮔﺮاﻧﻮﻟﻮزا و ﻫﻤﭽﻨﯿﻦ ﻣﺎﯾﻊ ﻓﻮﻟﯿﮑﻮﻟﯽ در ﺑﯿﻤﺎران pcos ﻧﺎﺑﺎرور ﺗﺤﺖ درﻣﺎن ﺑﺎ ﺗﮑﻨﯿﮏﻫﺎی ﮐﻤﮏ ﺑﺎروری ﮔﺰارش ﺷﺪه اﺳﺖ. ﻧﺘﯿﺠﻪﮔﯿﺮی: ﺑﻪ ﻧﻈﺮ ﻣﯽ رﺳﺪ ﻫﻤﺎﻫﻨﮕﯽ ﺑﯿﻦ ﺳﻪ ﻋﺎﻣﻞ اﺻﻠﯽ درﯾﺎﻓﺖ ﮐﺮﺑﻮﻫﯿﺪرات ﺑﺎﻻ از ﻃﺮﯾﻖ رژﯾﻢ ﻏﺬاﯾﯽ، ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﯿﻦ و ﻫﯿﭙﺮآﻧﺪروژﻧﯿﺴﻢ را ﻣﯽ ﺗﻮان آﻏﺎزﮔﺮ ﻓﺮآﯾﻨﺪ اﻟﻘﺎی اﻟﺘﻬﺎب و اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ در ﺑﯿﻤﺎران pcos داﻧﺴﺖ. ﻣﮑﻤﻞﻫﺎی آﻧﺘﯽ اﮐﺴﯿﺪاﻧﯽ و ﻋﻮاﻣﻞ ﺿﺪاﻟﺘﻬﺎﺑﯽ ﻣﯽ ﺗﻮاﻧﺪ در ﺑﻬﺒﻮد ﻧﺘﺎﯾﺞ ﺳﯿﮑﻞ ﻫﺎی درﻣﺎن ﻧﺎﺑﺎروری در اﯾﻦ ﺑﯿﻤﺎران ﻣﻔﯿﺪ ﺑﺎﺷﺪ. ﺑﺎ اﯾﻦ ﺣﺎل، ﺟﻤﻊ ﺑﻨﺪی ﻧﺘﺎﯾﺞ ﻫﻨﻮز ﺑﻪ ﻣﻄﺎﻟﻌﺎت ﺑﯿﺸﺘﺮی ﻧﯿﺎز دارد.

the role of inflammation and oxidative stress in the etiology of polycystic ovary syndrome: a review article

introduction: in recent years, the role of inflammation and oxidative stress in the etiology of polycystic ovary syndrome has received more attention. evaluation of the existing studies regarding the effects of inflammatory mediators and oxidative stress on ovarian function in patients with polycystic ovary syndrome (pcos) indicates the key role of these factors in the progress and development of disease complications. the current review study was conducted with aim to summarize the presence and role of the aforementioned inflammatory mediators as well as the effect of recent treatment approaches including the use of antioxidant supplements and anti-inflammatory agents in improving the results of infertility treatment cycles in these patients.methods: in the present review article, to find the related articles, databases of pubmed, science direct, scopus, and google scholar databases were searched with the keywords of polycystic ovary syndrome, inflammation, oxidative stress, oxygen-free radicals, antioxidant supplementation, infertility treatment, androgens, cytokines, and insulin resistance using the and and or operators from january 1991 to december 2020. results: after reviewing all the articles in this field, it was found that pcos, as a genetic and autoimmune disease, is associated with low degrees of inflammation, which plays an important role in the etiology, progression and occurrence of the disease. moreover, ovulatory dysfunction, increased concentrations of oxygen free radicals in granulosa cells, as well as the follicular fluid of infertile pcos patients under art treatment, have been reported.conclusion: it seems that the coordination between three main factors, namely high dietary carbohydrate intake, insulin resistance, and hyperandrogenism, can be considered as the initiator for inflammation induction and oxidative stress in pcos patients. the antioxidant supplements and anti-inflammatory agents can be useful to improve the results of infertility treatment cycles in these patients; however, concluding the results still requires further studies.