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   Use of monoclonal faecal elastase-1 concentration for pancreatic status assessment in cystic fibrosis patients [Utilidade da concentração da elastase-1 fecal monoclonal na avaliação da função pancreática nos pacientes com fibrose cística]  
   
نویسنده gonzales a.c.s. ,vieira s.m.g. ,maurer r.l. ,e silva f.a.a. ,silveira t.r.
منبع jornal de pediatria - 2011 - دوره : 87 - شماره : 2 - صفحه:157 -162
چکیده    Objective: to assess the concentration of faecal elastase-1 (el-1) in pediatric patients with cystic fibrosis with mutation δf508. methods: cross-sectional study with samples collected consecutively from 51 patients aged 4 months to 17 years old (mean 9.11±4.74); 32 (62.8%) patients were male. clinical-demographic data were collected,as well as data on the type of mutation. exocrine pancreatic insufficiency was established by the activity of faecal el-1 < 200 μg/g. el-1 was quantified through the monoclonal elisa method (schebo biotech ag,germany). pancreatic supplements were used in 46 (90.2%) patients. results: forty-one (80.4%) patients presented with pancreatic insufficiency (el-1 fecal < 100 μg/g): 17 (41.5%) were homozygous,14 were heterozygous (34.1%) and 10 were non-δf508 (24.4%). regarding the mutation,there was a statistically significant association of homozygosity with faecal el-1 concentration < 100 μg/g (p = 0.010). all patients considered to be pancreatic insufficient (n = 41) by the test were using pancreatic supplements. ten (19.6%) presented faecal el-1 > 200 μg/g,and 5/10 (50%) used enzymes. conclusions: the activity of faecal el-1 < 100 μg/g,indicating pancreatic insufficiency,was observed in 17/17 (100%) of homozygous patients,as expected,and was less frequent in patients who were heterozygous for δf508 and in patients without the mutation. there was no association of faecal el-1 concentration with age and sex of patients. the test was standardized,is easy to execute,and can be used to assess the pancreatic status of patients with cystic fibrosis. copyright © 2011 by sociedade brasileira de pediatria.
آدرس saúde da criança e do adolescente,universidade federal do rio grande do sul (ufrgs),porto alegre,rs, Brazil, serviço de pediatria,hospital de clínicas de porto alegre (hcpa),ufrgs,porto alegre,rs, Brazil, laboratório experimental de gastroenterologia e hepatologia,hcpa,ufrgs,porto alegre,rs, Brazil, departamento de pediatria e puericultura,ufrgs,porto alegre,rs, Brazil, laboratório experimental de gastroenterologia e hepatologia,hcpa,ufrgs,porto alegre,rs, Brazil
 
     
   
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