Peri-intraventricular hemorrhage and oxidative and inflammatory stress markers in very-low birth weight newborns

Objectives to evaluate the association between oxidative and inflammatory stress markers with peri-intraventricular hemorrhage (pivh) in very-low birth weight newborns. methods this was a prospective study conducted in a level iii neonatal unit. basal and stimulated reactive oxygen intermediates (rois),reduced glutathione (gsh),and interleukin-6 (il-6) levels were measured in umbilical cord blood. newborns underwent serial ultrasound at the bedside,at 6,12,24,and 72 hours of life and at seven days for the diagnosis of pivh,classified as grades i to iv. two groups were assessed,those with and without pivh; maternal and neonatal control variables were used for comparison. univariate and multiple regression analyses were applied. results a total of 125 newborns were assessed. pivh incidence rate was 12.0%. in the univariate analysis,basal roi,the use of two or more doses of corticosteroids,birth weight < 1,000 g,ventilatory support use,and snappe ii value ≥ 22 were significantly associated with pivh. however,in the multivariate analysis,only antenatal steroid use was independently associated with the disease (or 0,194; 95% ci: 0,048 to 0,773; p=0,02). conclusion roi,gsh,and il-6 levels were not associated with the occurrence of pivh in very-low birth weight infants © 2015 sociedade brasileira de pediatria. published by elsevier editora ltda. all rights reserved.