Acute Myeloid Leukemia: Analysis of epidemiological profile and survival rate

Objective to describe the epidemiological profile and the survival rate of patients with acute myeloid leukemia (aml) in a state reference pediatric hospital. method clinical-epidemiological,observational,retrospective,descriptive study. the study included new cases of patients with aml,diagnosed between 2004 and 2012,younger than 15 years. results of the 51 patients studied,84% were white; 45% were females and 55%,males. regarding age,8% were younger than 1 year,47% were aged between 1 and 10 years,and 45% were older than 10 years. the main signs/symptoms were fever (41.1%),asthenia/lack of appetite (35.2%),and hemorrhagic manifestations (27.4%). the most affected extra-medullary site was the central nervous system (14%). in 47% of patients,the white blood cell (wbc) count was below 10,000/mm3 at diagnosis. the minimal residual disease (mrd) was less than 0.1%,on the 15th day of treatment in 16% of the sample. medullary relapse occurred in 14% of cases. when comparing the bone marrow mrd with the vital status,it was observed that 71.42% of the patients with type m3 aml were alive,as were 54.05% of those with non-m3 aml. the death rate was 43% and the main proximate cause was septic shock (63.6%). conclusions in this study,the majority of patients were male,white,and older than 1 year. most patients with wbc count <10,000/mm3 at diagnosis lived. overall survival was higher in patients with mrd <0.1%. the prognosis was better in patients with aml-m3. © 2016 sociedade brasileira de pediatria.