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   A randomized controlled trial of the laryngeal mask airway for surfactant administration in neonates [Ensaio controlado randomizado de máscara laríngea para administração de surfactantes em neonatos]  
   
نویسنده barbosa r.f. ,simões e silva a.c. ,silva y.p.
منبع jornal de pediatria - 2017 - دوره : 93 - شماره : 4 - صفحه:343 -350
چکیده    Objective to compare the short-term efficacy of surfactant administration by laryngeal mask airway versus endotracheal tube. methods preterm infants (28–35 weeks of gestational age),weighing 1 kg or more,with respiratory distress syndrome,requiring nasal continuous positive airway pressure,with increased respiratory effort and/or fraction of inspired oxygen (fio2) ≥ 0.40 to maintain oxygen saturation 91–95%,were randomized to receive surfactant by lma following ncpap or by ett following mechanical ventilation (mv). the primary outcome was a clinical response defined as fio2 ≤ 0.30 three hours after surfactant. secondary outcomes for lma group were: need of surfactant retreatment during the first 24 h,mv requirement,and presence of surfactant in gastric content. results forty-eight patients were randomized; 26 in the lma group and 22 in the ett group. six of 26 patients (23%) in the lma group and five of 22 patients (22.7%) in the ett group did not meet the primary outcome (p = 0.977). fourteen (53.8%) of the lma patients were not intubated nor ventilated; 12 (46.1%) were ventilated: for surfactant failure (23%),for ncpap failure (11.5%),and for late complications (11.5%). groups were similar regarding prenatal status,birth conditions,and adverse events. no significant gastric content was found in 61.5% of the lma patients. oxygen and second dose surfactant requirements,arterial/alveolar ratio,and morbidities were similar among groups. conclusions surfactant administration by lma showed short-term efficacy,with similar supplementary oxygen need compared to surfactant by ett,and lower mv requirement. further studies with larger sample size are necessary to confirm these results. © 2017 sociedade brasileira de pediatria
کلیدواژه Laryngeal mask airway; Preterm infant; Pulmonary surfactant
آدرس universidade federal de minas gerais (ufmg),faculdade de medicina,departamento de pediatria,laboratório interdisciplinar de investigação médica,belo horizonte,mg,brazil,maternidade unimed-bh,unidade de terapia intensiva neonatal,belo horizonte,mg, Brazil, universidade federal de minas gerais (ufmg),faculdade de medicina,departamento de pediatria,laboratório interdisciplinar de investigação médica,belo horizonte,mg, Brazil, universidade federal de minas gerais (ufmg),faculdade de medicina,departamento de pediatria,laboratório interdisciplinar de investigação médica,belo horizonte,mg,brazil,hospital lifecenter,departamento de anestesia,belo horizonte,mg, Brazil
 
     
   
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