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Effects of Trans-Resveratrol, Isolated from Smilax Aspera, on Smooth Muscle, Blood Pressure, and Inflammation in Rats and Nociception in Mice
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نویسنده
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Harb Abeer H. ,abu Zarga Musa ,Abdalla Shtaywy
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منبع
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jordan journal of biological sciences - 2009 - دوره : 2 - شماره : 2 - صفحه:69 -76
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چکیده
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Smilax aspera (liliaceae) has been used in herbal medicine for the treatment of many disorders. chemical analysis of this plant resulted in the isolation of the stilbene trans-resveratrol. the effects of this compound on rat isolated ileum and urinary bladder, blood pressure and inflammation, and nociception in mice have been examined. resveratrol (3x10-5 -1x10-1 mg/ml; or 1.3x10 7 - 4.4x10-4 m) caused a concentration-dependent relaxation in both ileal longitudinal segments and urinary bladder rings. intravenous doses of resveratrol (0.028- 8.5 mg/kg) caused a dose-dependent fall of systolic and diastolic blood pressure of anesthetized rats. oral administration of this compound (1.3, 4.0. 13 and 40 mg/kg) decreased carrageenan-induced paw edema in rats. furthermore, oral administration of resveratrol (3, 10, 30 and 100 mg/kg) decreased the number of writhes induced by i.p. injection of 0.8% acetic-acid in mice. these effects of resveratrol and its potential as a medicinal source were discussed in the light of the reported effects of resveratrol on nitric oxide and prostaglandin synthesis
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کلیدواژه
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Resveratrol; Smilax Aspera; Smooth Muscle; Blood Pressure; Inflammation; Analgesia
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آدرس
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University of Jordan, Department of Biological Sciences, Jordan, University of Jordan, Dept of Chemistry, Jordan, University of Jordan, Dept of Biological Sciences, Jordan
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پست الکترونیکی
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shtaywy@ju.edu.jo
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Authors
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