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Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
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نویسنده
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fernandes l.a. ,martins t.m. ,de almeida j.m. ,nagata m.j.h. ,theodoro l.h. ,garcia v.g. ,bosco a.f.
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منبع
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journal of applied oral science - 2010 - دوره : 18 - شماره : 6 - صفحه:635 -640
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چکیده
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Objective: the aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (ttc-hcl) as adjunctive treatment to scaling and root planning (srp) on induced periodontitis in rats. material and methods: in 60 rats,periodontal disease was ligature-induced at the mandibular left first molar. after 7 days,the ligature was removed and all animals were submitted to srp,and divided into 2 groups according to the following treatment: c (n = 30) - subgingival irrigation with 1 ml of saline; t (n = 30) - subgingival irrigation with 1 ml of ttc-hcl (50 mg/ml). ten animals in each group were euthanized at 7,15 and 30 days posttreatment. the histometric values were statistically analyzed (p<0.05). results: in the histometric analysis,at 7,15 and 30 days,group t (0.72±0.05 mm2,0.57±0.14 mm2,0.62±0.07 mm2),showed less bone loss (p<0.05) than group c (1.35±0.25 mm2; 1.40±0.31 mm2; 1.29±0.27 mm2),respectively. conclusions: subgingival irrigation with ttc-hcl was an effective adjunctive treatment for periodontal disease induced in rats.
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کلیدواژه
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Irrigation; Periodontal diseases; Periodontitis; Rats; Tetracycline
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آدرس
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department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil, department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil, department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil, department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil, department of periodontics,barretos dental school,university center of educational foundation of barretos,barretos,sp, Brazil, department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil, department of surgery and integrated clinic,araçatuba dental school,são paulo state university,araçatuba,sp, Brazil
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Authors
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