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Effect of an acrylic resin combined with an antimicrobial polymer on biofilm formation
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نویسنده
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marra j. ,paleari a.g. ,rodriguez l.s. ,leite a.r.p. ,pero a.c. ,compagnoni m.a.
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منبع
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journal of applied oral science - 2012 - دوره : 20 - شماره : 6 - صفحه:643 -648
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چکیده
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Objectives: the purpose of this study was to evaluate the antimicrobial activity of an acrylic resin combined with an antimicrobial polymer poly (2-tert-butylaminoethyl) methacrylate (ptbaema) to inhibit staphylococcus aureus,streptococcus mutans and candida albicans biofilm formation. material and methods: discs of a heat-polymerized acrylic resin were produced and divided according to ptbaema concentration: 0 (control),10 and 25%. the specimens were inoculated (107 cfu/ml) and incubated at 37°c for 48 h. after incubation,the wells were washed and each specimen was sonicated for 20 min. replicate aliquots of resultant suspensions were plated at dilutions at 37°c for 48 h. the number of colony-forming units (cfu) was counted and expressed as log (cfu+1)/ml and analyzed statistically with α=.05. results: the results showed that 25% ptbaema completely inhibited s. aureus and s. mutans biofilm formation. a significant reduction of log (cfu+1)/ml in count of s. aureus (control: 7.9±0.8a; 10%: 3.8±3.3b) and s. mutans (control: 7.5±0.7a; 10%: 5.1±2.7b) was observed for the group containing 10% ptbaema (mann-whitney,p<0.05). for c. albicans,differences were not significant among the groups (control: 6.6±0.2a; 10%: 6.6±0.4a; 25%: 6.4±0.1a),(kruskal-wallis,p>0.05,p=0.079). conclusions: acrylic resin combined with 10 and 25% of ptbaema showed significant antimicrobial activity against s. aureus and s. mutans biofilm,but it was inactive against the c. albicans biofilm.
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کلیدواژه
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Acrylic resins; Biofilms; Dental materials; Polymers
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آدرس
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department of prosthodontics,paulista university-unip,goiânia,go, Brazil, department of dental materials and prosthodontics,araraquara dental school,univ. estadual paulista-unesp,rua humaitá,1680,14801-903-araraquara-sp, Brazil, department of dental materials and prosthodontics,araraquara dental school,univ. estadual paulista-unesp,rua humaitá,1680,14801-903-araraquara-sp, Brazil, department of dental materials and prosthodontics,araraquara dental school,univ. estadual paulista-unesp,rua humaitá,1680,14801-903-araraquara-sp, Brazil, department of dental materials and prosthodontics,araraquara dental school,univ. estadual paulista-unesp,rua humaitá,1680,14801-903-araraquara-sp, Brazil, department of dental materials and prosthodontics,araraquara dental school,univ. estadual paulista-unesp,rua humaitá,1680,14801-903-araraquara-sp, Brazil
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Authors
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