FASN expression,angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

Central giant cell lesion (cgcl) and peripheral giant cell lesion (pgcl) are non-neoplastic proliferative processes of the jaws. pgcl is a reactive process induced by irritant local factors and cgcl is an intra-osseous lesion of unknown etiology. both lesions exhibit similar histologic features showing abundant mononuclear cells,admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes,hemosiderin deposition,and blood-filled pools. recent studies have linked fatty acid synthase (fasn) with angiogenesis. objective: to evaluate angiogenesis and lymphangiogenesis and their relationship with fasn expression in cgcl and pgcl. material and methods: thirteen cgcl and 14 pgcl of the jaws were selected for immunoexpression of fasn; cd34 and cd105 (to assess blood microvessel density [mvd] and microvessel area [mva]); and d2-40 (to assess lymphatic mvd and mva). results: within pgcl and cgcl,mvd-cd34 was significantly higher than mvd-cd105,followed by mvd-d2-40. moreover,a significantly higher number of fasn-positive multinucleated giant cells than mononuclear cells were observed. between pgcl and cgcl,only mvd-cd34 and all mva were significantly higher in pgcl. positive correlation between mva-cd105 with fasn-positive mononuclear cells in both lesions was observed. conclusions: our results show both lesions exhibiting similar levels of fasn expression and neoangiogenesis,suggesting constitutive processes that regulate tissue maintenance.