Effectiveness of a new non-hydrogen peroxide bleaching agent after single use - A double-blind placebo-controlled short-term study

Tooth whitening represents perhaps the most common aesthetic procedure in dentistry worldwide. the efficacy of bleaching depends on three aspects: bleaching agent,bleaching method,and tooth color. objective: this in vivo study aimed to examine whitening effects on frontal teeth of the upper and lower jaws using an over-the-counter (otc) non-hydrogen peroxide bleaching agent in comparison to a placebo after one single use. material and methods: forty subjects (25 female; 15 male) participated in this double-blind randomized placebo-controlled trial. the subjects were randomly allocated to two groups (n=20). the test group received the otc product (iwhite instant) and the placebo group received an identically composed product except for the active agents. each subject was treated with a prefilled tray containing iwhite instant or the placebo for 20 minutes. the tooth shade of the front teeth (upper and lower jaws) was assessed before (e_0),immediately after (e_1) and 24 h after treatment (e_2),using a shade guide (vita classical). statistical testing was accomplished using the mann-whitney u test (p<0.001). the dropout rate was 0%. results: there were no significant differences at e_0 between placebo and test groups regarding the tooth color. differences in tooth color changes immediately after (δe1_0) and 24 h after treatment (δe2_0) were calculated for both groups. the mean values (standard deviations) of tooth color changes for δe1_0 were 2.26 (0.92) in the test group and 0.01 (0.21) in the placebo group. the color changes for δe2_0 showed mean values of 2.15 (1.10) in the test group and 0.07 (0.35) in the placebo group. for δe1_0 and δe2_0 significant differences were found between the groups. conclusion: in this short-term study,the results showed that a non-hydrogen peroxide bleaching agent has significant whitening effects immediately and 24 h after a single-use treatment. © 2017,faculdade de odontologia de bauru. all rights reserved.