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Inhibition of blood and tissue cholinesterases by soman in guinea pigs in vivo
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نویسنده
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bajgar j. ,kassa j. ,pohanka m. ,karasová j.z. ,novotný l. ,fusek j. ,bláha v.
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منبع
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journal of applied biomedicine - 2011 - دوره : 9 - شماره : 1 - صفحه:35 -41
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چکیده
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Guinea pigs were intoxicated intramuscularly with different doses of soman,and cholinesterase activities were determined in the blood,diaphragm and parts of the brain - the pontomedullar area,the frontal cortex and the basal ganglia. the time course of poisoning following low doses (1,3,5 μg/kg) and a dose equal to 1×ld50 (28.5 μg/kg) were studied. the dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1-3 μg/kg,and,following administration of a dose of 5 μg/kg,statistically significant blood cholinesterase inhibition was demonstrated.
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کلیدواژه
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Blood; Brain parts; Cholinesterases; Guinea pig; Inhibition in vivo; Soman
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آدرس
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department of toxicology,faculty of military health sciences,university of defence,hradec králové, Czech Republic, department of toxicology,faculty of military health sciences,university of defence,hradec králové, Czech Republic, center of advanced studies,faculty of military health sciences,university of defence,hradec králové, Czech Republic, department of toxicology,faculty of military health sciences,university of defence,hradec králové, Czech Republic, central vivarium,faculty of military health sciences,university of defence,hradec králové, Czech Republic, department of toxicology,faculty of military health sciences,university of defence,hradec králové, Czech Republic, department of public health,faculty of military health sciences,university of defence,hradec králové, Czech Republic
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Authors
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