A cherry nutraceutical modulates melatonin,serotonin,corticosterone,and total antioxidant capacity levels: Effect on ageing and chronotype

Impaired daily rhythms in vertebrate physiology occur with age. particularly,age-related changes in melatonin and serotonin rhythms and hypercortisolemia have been reported to be linked to age-related disorders. this study was aimed at assessing the effect of a jerte valley cherry-based nutraceutical product (patent no es 2342141 b1),which contains high levels of tryptophan,serotonin,and melatonin,on the serum melatonin,serotonin,corticosterone,and total antioxidant capacity (tac) levels in young and old ring doves (streptopelia risoria) and rats (rattus norvegicus) as representatives of animals with diurnal and nocturnal habits,respectively. the animals consumed the cherry product for 10 days. serum melatonin,serotonin,corticosterone,and tac were measured with commercial elisa kits. the consumption of the cherry product induced a significant increase in the circulating levels of melatonin and serotonin,as well as in the serum tac and a significant decrease in the circulating levels of corticosterone in both species and groups of age as compared to their respective values in the control groups. the consumption of a jerte valley cherry-based nutraceutical product may help to counteract the decrease in melatonin and serotonin and the increase in oxidative stress,suggesting a potential health benefit especially in aged populations where these parameters have been found to be altered. © journal of applied biomedicine.