Reactivation of organophosphate inhibited acetylcholinesterase activity by α,ω-bis-(4-hydroxyiminomethylpyridinium)alkanes in vitro

In this article,we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chain between two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. α,ω-bis(4- hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. these oximes differ in the number of methylene groups on the connecting chain. a three or four membered linking chain seems to be the ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. in this case,the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain.