Comparison of the neuroprotective effects of a novel bispyridinium oxime KR-22934 with the oxime K203 and obidoxime in tabun-poisoned male rats

The neuroprotective effects of a novel oxime kr-22934,the oxime k203 and obidoxime in combination with atropine in rats poisoned with tabun at a sublethal dose (200 μg/kg i.m.; 80% ld50) were studied. the tabun-induced neurotoxicity was monitored at 24 h following tabun challenge using a functional observational battery and an automatic measurement of motor activity. the results indicate that all tabun-poisoned rats treated with oximes in combination with atropine were able to survive within 24 h following tabun poisoning. one tabun-poisoned rat without antidotal treatment died within 24 h. the oximes kr-22934 and k203 combined with atropine showed a similar potency to decrease tabun-induced neuro-toxicity at 24 h after tabun administration while the neuroprotective efficacy of obidoxime was slightly higher. however,no oxime was able to eliminate tabun-induced neurotoxicity completely. when atropine was administered alone,negligible neuroprotective efficacy was observed. based on the results,a novel oxime kr-22934 did not bring any improvement of the neuroprotective efficacy of antidotal treatment of acute tabun poisonings. © 2013 faculty of health and social studies,university of south bohemia in ceske budejovice. published by elsevier urban & partner sp. z o.o. all rights reserved.