Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Sulfate-reducing bacteria (srb) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (ibd); unfortunately present antibacterial chemotherapeutics used in the treatment of ibd have been ineffective. thus,the antimicrobial activity of salicylamide derivatives against two different genera of intestinal srb,desulfovibrio and desulfomicrobium,was investigated. six 2-(phenylcarbamoyl)phenyl n-[(benzyloxy)carbonyl]alkanoates and three 2-hydroxy-n-[(2s)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed mic values in the range from 0.22 to 0.35 μm against desulfovibrio piger vib-7 and in the range from 0.27 to 8.52 μm against desulfomicrobium sp. rod-9,while mic values of ciprofloxacin were 41.2 μm and 39.3 μm. the highest potency against the two strains was observed for 4-chloro-n-{(2s)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (mic 0.22 μm and 0.27 μm). 4-chloro-2-[(4-nitrophenyl)carbamoyl]phenyl (2s)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate showed high activity against d. piger vib-7 (mic = 0.26 μm),while 4-chloro-2-[(4-methylphenyl)carbamoyl]phenyl (2s)-2-[(tert-butoxycarbonyl)amino]-3-(1h-indol-2-yl)propanoate expressed high activity against desulfomicrobium sp. rod-9 (mic = 0.31 μm). structure-activity relationships are discussed. © 2015 faculty of health and social studies,university of south bohemia in ceske budejovice. published by elsevier sp. z o.o. all rights reserved.