Overt hypothyroidism is associated with blood inflammatory biomarkers dependent of lipid profile

To investigate the association between inflammatory biomarkers and overt hypothyroidism (oh). we measured inflammatory cytokines,interleukin-1 (il-1),interleukin-6 (il-6),tumor necrosis factor-α (tnf-α) and interferon-γ (ifn-γ) as well as cell-free dna (cf-dna) levels in 40 oh patients and 40 healthy controls. total cholesterol,high and low density lipoprotein subfractions,triglyceride,fibrinogen,and d-dimer were recorded. increased inflammatory profile was evidenced through significant elevations in the concentrations of all cytokines and cf-dna levels in the oh group. lipids and prothrombotic markers were also increased in hypothyroid subjects. a significant association between the inflammatory cytokines and lipid profile was observed. a multivariate analysis showed that this result was independent of the sex,age and bmi status of the subjects. hypothyroidism is associated with proinflammatory state. lipid abnormalities have a stronger influence on inflammation,increasing cardiovascular risk and atherosclerosis development in hypothyroidism. © 2015 faculty of health and social studies,university of south bohemia in ceske budejovice. published by elsevier sp. z o.o. all rights reserved.