Exercise-induced epigenetic regulations in inflammatory related cells

Physical activity has been correlated with transient immune impairment. however,such activities lead to improvement in immunity rather than dysfunction. the major benefit of regular exercise is the reduction of low-grade inflammation which consequently prevents or attenuates metabolic diseases,such as atherosclerosis and type 2 diabetes,neurodegenerative disorders,cancer or even depression. as a major factor responsible for general improvements in the immune system,scientists have examined epigenetics. epigenetic mechanisms include cytosine methylation,micro-rna expression and post-transcriptional modifications of histones,which regulate tissue-specific gene expression in response to environmental stimulation. this review will summarize the recent data regarding the impact of exercise and the role of epigenetic mechanisms on gene expression changes in peripheral blood mononuclear cells (pbmcs). © 2016