Delta index of the estimated glomerular filtration rate to amend the overestimated Neutrophil Gelatinase-Associated Lipocalin (NGAL) level in systemic inflammatory response syndrome

This study aimed to investigate a delta index of the estimated glomerular filtration rate (δegfr-index) to amend an overestimated neutrophil gelatinase-associated lipocalin (ngal) level in systemic inflammatory response syndrome (sirs). a δegfr-index was computed,and the ngal/δegfr-index was determined. patients with sirs exhibited significantly higher levels in ngal,the δegfr-index,and high sensitivity c-reactive protein (hscrp) than non-sirs inflammatory patients (216 ng/ml,1.32,and 5.64 mg/dl vs. 153 ng/ml,1.18,and 2.92 mg/dl,respectively,p < 0.05). after adjusting for potential confounders,the ngal/δegfr-index was closely associated with serum hscrp concentrations (standard β = 0.552,p < 0.001). in a receiver operating characteristic curve,the diagnostic ability of the ngal/δegfr-index to identify sirs in inflammatory diseases was superior to that of the ngal [0.712 (95% ci,0.638-0.786) vs. 0.646 (95% ci,0.567-0.726),p < 0.001]. the area under the curve of the ngal/δegfr-index was significantly larger than that of ngal for detecting hscrp >3.80 mg/dl in sirs [0.761 (95% ci,0.660-0.862) vs. 0.728 (95% ci,0.625-0.831),p = 0.019]. in short,the ngal/δegfr-index more correctly represents the disease activity in sirs than the level of plasma ngal. a measure of the ngal/δegfr-index may be of additional help when monitoring patients with sirs,particularly in conjunction with concurrent renal dysfunction. © 2017