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Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function
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نویسنده
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totoskovic d. ,dopsaj v. ,martinovic j.
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منبع
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journal of applied biomedicine - 2017 - دوره : 15 - شماره : 3 - صفحه:204 -209
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چکیده
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The purpose of the present study was to investigate neutrophil and monocyte cell population data as novel markers of low cobalamin/folate concentrations and influence of renal function on their usefulness. the study included 284 patients older than 60 years or with dyspepsia symptoms with mean corpuscular volume 80–100 fl and c-reactive protein ≤ 50 mg/l. subjects were divided according to renal function and further classified based on cobalamin and folate levels. neutrophil and monocyte volume (nev,mov),conductivity (nec,moc),light scatter (nes,mos) and standard deviations (nev-sd,mov-sd,nec-sd,moc-sd,nes-sd,mos-sd),obtained by coulter lh750® hematology analyzer (beckman coulter,usa),were evaluated along with white blood cell count,hemoglobin,hematocrit,red cell distribution width and homocysteine relative to renal function and cobalamin/folate status. neutrophil conductivity standard deviation (nec-sd) had the largest magnitude of the difference between patients with low and normal vitamin levels,was the strongest predictor of low cobalamin/folate concentrations and had the largest area under the curve in detection of vitamin deficiency. patients with different renal function status and the same cobalamin/folate status did not differ in nec-sd. in this selected group of patients,nec-sd was marker of low cobalamin and folate levels regardless of the renal function. © 2017
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کلیدواژه
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Cell population data; Cobalamin/folate deficiency; Monocyte; Neutrophil; Renal function
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آدرس
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faculty of pharmacy,faculty of pharmacy,department of medical biochemistry,belgrade, Serbia, faculty of pharmacy,faculty of pharmacy,department of medical biochemistry,belgrade,serbia,clinical centre of serbia,center of medical biochemistry,belgrade, Serbia, health center rakovica,laboratory department,belgrade, Serbia
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Authors
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