Effect of the oil extract of Ocimum gratissimum leaves on the reproductive function and fertility of adult male rats

To study the effect of the oil extract of ocimum gratissimum leaves on male reproductive function and fertility in of adult male rats. 18 male rats,3-4 months old,weighing 220-260 g were administered (by gastric intubation) the oil extract of ocimum gratissimum leaves at two doses,100 and 300 mg/kg for 60 days. the control group received distilled water for the same duration. after the end administration,male rats coupled with coeval female rats. then animals were sacrificed and the blood,testes,epididymis,were collected for parameters analyses and fertility percentage. there was a significant decrease in the gsi(p<0.01),sperm motility(p<0.05),sperm viability(p<0.001),esr(p<0.001),dsp(p<0.05),level of testosterone in the serum(p<0.05) and fertility percentage(p<0.01) after days of treatment in treated rats with high dose. the oil extract of ocimum gratissimum leaves at dose (300 mg/kg) had a negative impact on the male reproductive function and fertility.