COMPARATIVE ANALYSIS OF EUGENOL COMPOUND AND OCIMUM SANCTUM LINN. LEAF EXTRACT ON THE INFERTILITY IN FEMALE ALBINO RATS

The present study is aimed to monitor the effect of eugenol and os leaf extract on the antifertility activity through hostological observations and assaying of antioxidant enzymes in female rats. the female rats of 170±20g weight were administered with eugenol (99% pure) @ 0.4 ml/day/rat and os leaf extract @ 500 mg/kg body weight/ orally for 15 days. the present investigation the catalase levels were significantly increased in liver by both administrations (p<0.001). the ast and alt levels were significantly elevated in liver by both administrations (p<0.001). the histology of the ovary by the administration of eugenol, showing disorganization of granulose cells and the graafian follicle shows the characteristics of follicular atresia. the significantly elevated astactivitys levels in liver tissue clearly demonstrate the liver dysfunctioning and disturbance in the production rates of antioxidant enzymes. the histological observation clearly demonstrates that due to administration of eugenol, ovary weight was significantly reduced, whereas progressive diminishment in the follicular apparatus and primary follicles.