Loperamide Dependency: A Case Report

Background: loperamide is used as an antidiarrheal drug and is available over-the-counter. it cannot pass the blood-brain barrier and it does not have a considerable abuse potential. it can lead to dangerous cardiac arrhythmia. case report: herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. he underwent detoxification for using 200 mg loperamide daily with anticholinergic agents, clonidine, non-steroidal analgesics, and diazepam. no evidence of arrhythmia was seen in the patient. conclusion: tolerating high doses of loperamide could be dangerous and increases the risk of fatal cardiac arrhythmias.