quercetin supplementation has no synergetic effect with high-intensity interval training in ameliorate lipid profile in male diabetic rats

Background: in diabetic patients, lipid profile (lp) management is crucial. quercetin (que), as an antioxidant supplement, has received a great deal of attention in improving the lp. objectives: the current study aimed to investigate the simultaneous effect of high-intensity interval training (hiit) and que on lp in male diabetic rats. methods: fifty wistar male rats were randomly assigned to healthy control (hc; n = 10), diabetic control (dc; n = 10), high-intensity interval training (hiit; n = 10), quercetin supplement (qs; n = 10), high-intensity interval training and quercetin (hiiq; n = 10). que was given (20 mg/kg/d) to the animals daily for six weeks. hiit has performed five sessions per week for six weeks in 8-10 sets with 85 - 65% of the maximum oxygen consumption (vo2max) on the treadmill. blood samples were taken directly from the animal’s heart 48 hours after the last training session, and high-density lipoprotein (hdl-c), low-density lipoproteins (ldl-c), triglycerides (tg) cholesterol (chol), and fasting blood glucose (fbs) were measured in the serum. to analyze the data, two-way analysis of variance (anova) and tukey's post hoc test were used. results: there was no significant difference between hiiq with hiit, qs in ldh-c and ldl-c (p > 0.05). also, no significant difference was seen between hiit, qs, and hiiq in tg concentration after intervention (p > 0.05). chol was significantly lower in hiit than qs (p = 0.001), while there was no significant difference between the hiiq with qs (p > 0.05). also, there was no significant difference between qs and hiiq in fbs (p > 0.05). conclusions: it seems that high-intensity interval training and quercetin alone can be effective in improving lipid profile. however, quercetin does not have a synergetic effect with high-intensity interval training in ameliorating lipid profile in diabetic male rats.