comparison of the effects of two different intensities of combined training on irisin, betatrophin, and insulin levels in women with type 2 diabetes

Background: betatrophin is a β-cell proliferation marker produced as a result of irisin expression. it is regarded as a therapeutic indicator of diabetes due to elevated insulin secretion. objectives: the purpose of this study was to compare the effects of 2 different intensities of combined training on the levels of irisin, betatrophin, and insulin in women with type 2 diabetes. methods: in this study, 26 female patients with type 2 diabetes were divided into 3 groups of combined high-intensity training, combined moderate-intensity training, and control. the training groups participated in combined training at high or moderate intensities for 8 weeks. the variance analysis test and the duncan post-hoc test were applied to analyze the data (p > 0.05). results: combined training at 2 intensities of moderate and vigorous led to a rise in the levels of irisin, betatrophin, and insulin. exercise intensity was a determining factor for these elevated levels insofar as combined high-intensity training resulted in higher levels of these hormones than combined moderate-intensity training. conclusions: it appears that participating in relatively high-intensity training programs may be beneficial for diabetic patients inasmuch as they increase the levels of irisin, betatrophin, and then, insulin.