inflammatory and biochemical biomarkers in response to high intensity resistance training in trained and untrained men

Background: a session of resistance training (rt) will lead to metabolic and inflammatory changes. the aim of this study is to investigate metabolic and inflammatory changes in trained and untrained men. methods: twenty-eight young healthy men (14 trained and 14 untrained people) participated in this present study. to assess metabolic and inflammatory responses and muscle damage, blood samples were gathered before, immediately and 1 hour after training. results: the percentage of muscle mass and baseline ck activity were significantly greater within the trained than the untrained group. after conducting a rt session, there was a significant reduction in insulin concentration and resistance within the two groups and in blood glucose only within the untrained group. in addition, rt was also associated with an increase in muscle damage biomarkers, ck, and ldh after training. unlike ck, the activity of ldh was reduced during 1 hour of training (p < 0.05). among the different inflammatory markers, only il-6 concentration significantly increased within the two groups, which remained after 1 hour of training at the untrained group (p < 0.05). conclusions: the results of this study have shown that a rt session causes metabolic and inflammatory changes. the inflammatory response is significantly greater among subjects within the untrained group. moreover, blood pressure response was also greater within the untrained group, which is directly related to the training intensity. however, there were no significant differences in metabolic responses and muscle damages between the trained and untrained subjects.