Effect of Omega-3 Supplementation on Visfatin, Adiponectin, and Anthropometric Indices in Women with Polycystic Ovarian Syndrome

Background: polycystic ovary syndrome (pcos) is a multifactorial, metabolic disorder. characteristics are chronic anovulation, polycystic ovaries and hyperandrogenism. the aim of this study was to determine the effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in pcos women. methods: the study was a randomized double blind placebo-controlled clinical trial. it was conducted on 84 women with polycystic ovary syndrome (26.92±5.05 years, bmi=31.69 kg/m²) who referred to the fertility and infertility research center and shahid sadoughi hospital in yazd. after the examination, evaluation and paramedical assessment by obstetrician, they were recruited. they took 3 capsules of omega-3 (each one contained 180 mg epa and 120 mg dha) or placebo (each contained 1 g paraffin) daily for 8 weeks. statistical analysis was paired t-test and student t-test, and a p<0.05 was considered statistically significant. results: after the intervention, visfatin concentration did not change in neither groups. but, at the end of the study, the mean of adiponectin concentration increased (p<0.001) in omega-3 group. moreover, the mean of changes in this factor was significantly different between groups (p<0.005). fsh did not change in two groups of the study. however, the mean of lh decreased about 1.74 mlu/ml in omega-3 group (p<0.005). the mean of change of lh/fsh ratio between groups was significant (p<0.05). after the intervention, prolactin did not meaningfully change in both groups. conclusion: our results showed that 8 weeks of supplementation of omega-3 may have some beneficial effects on pcos biochemical characteristics such as lh, lh/fsh, and adiponectin.