Evaluation of Interleukin-10 (G-1082a) Promoter Polymorphism in Preeclampsia

Background: preeclampsia is a pregnancy-specific syndrome that may be lifethreatening, especially to the fetus. several causes have been reported that may have a possible role in the development of the disorder. interleukin-10 affect maternal intravascular inflammation, as well as endothelial dysfunction. the aim of this study was to investigate the association between il-10 g-1082a polymorphism and preeclampsia. methods: a total of eighty−eight pregnant women with preeclampsia and 100 women with normal pregnancy attending the gynecological unit of government maternity hospital, petlaburz, hyderabad, india, were considered for the study. a standard amplification refractory mutation system (arms) pcr was carried out for genotyping il-10 g-1082a promoter polymorphism in all the participants. genotypic distribution of the control and patient groups were compared with values predicted by hardy-weinberg equilibrium using χ2 test. odd ratios (or) and their respective 95% confidence intervals were used to measure the strength of association between il-10 gene polymorphism and preeclampsia. results: the frequencies of il-10 g-1082a genotypes, gg, ga and aa, were 17.8%, 41.09% and 41.09% in women with preeclampsia and 25%, 28% and 47% in the controls respectively. there was no significant difference in the distribution of genotypes and alleles of il-10 g-1082a between the two groups (test power=0.66). conclusion: the present study suggests that the il-10 g-1082a gene promoter polymorphism is not a major genetic regulator in the etiology of preeclampsia.