Outcomes of Preimplantation Genetic Testing for Single Gene Defects in a Privately Funded Period and Publicly Funded Period: A North-American Single Center Experience

Background: the purpose of this study was to assess whether the outcomes from ivf-preimplantation genetic testing (ivf-pgt) cycles for single gene defects (sgd) (pgt-m) differ between a privately funded period (prp) and publicly funded period (pup). methods: a retrospective cohort study was conducted in a north-american single tertiary center. the prp (march 1998 to july 2010) comprised 56 pgt-m cycles from 58 ivf cycles in 38 couples, and the pup (august 2010 to may 2015) comprised 59 pgt-m cycles from 87 ivf cycles in 38 couples. one pgt-m cycle is defined as one biopsy procedure from one or serial ivf cycles. a p-value of 0.05 was considered statistically significant. results: the clinical pregnancy rates (cpr) per pgt-m cycle were 30.4% and 52.5% in each period, respectively (p=0.021). the live birth rates (lbr) per pgt-m cycle were 21.5% versus 40.9% in each period, respectively (p=0.037). a sub-analysis within the pup comparing 39 pgt-m cycles from 39 ivf cycles with 20 pgtm cycles from 49 ivf cycles yielded cprs per pgt-m cycle of 64.1% and 30.0% and lbrs per pgt-m cycle of 53.8% and 15.0%, in each group, respectively (p< 0.05 for both). conclusion: the transition from private to public funding and a single embryo transfer (et) guideline has little impact on embryological and clinical outcomes of pgt-m cycles, and results in lower rates of multiple pregnancies. however, these two systems may serve different populations.