A Novel De Novo Chromosomal Insertion, 46 Xx, Ins(7:13)(P14; Q14.2q21.1) Is Related To the Embryo Development Arrest Following Assisted Reproductive Technique

Background: infertility is a problem affecting a large number of couples in the world. one of the causes of infertility can be chromosomal rearrangements such as insertions. in this case report study, the outcome of two intra-cytoplasmic sperm injection (icsi) cycles of an infertile woman with de novo chromosomal insertion is explained. case presentation: a couple with a 10-year history of infertility referred to our infertility clinic. the husband had a daughter in his first previous marriage. the wife had a 7 and a 10 year history of infertility in the first and second marriages, respectively. in the first marriage, she reported a history of 2 failed intra-uterine insemination (iui) cycles. in the second marriage, she had a history of 1 spontaneous abortion at 12 weeks of pregnancy, 4 failed iui cycles, and 1 failed icsi cycle. the couple was subjected to icsi cycles twice and failed due to embryo development arrest. the couple referred for karyotyping. the husband showed a normal male karyotype. in comparison, the wife revealed an abnormal female karyotype with two rearrangements: chromosome 13 with an interstitial deletion between bands q14.2 and q21.1, and a derivative chromosome 7 containing this segment of chromosome 7 as an insertion onto short arm at the p14 position. conclusion: to the best of our knowledge, this is the first report of insertion 46 xx, ins(7:13)(p14; q14.2q21.1) which is associated with the embryo development arrest following assisted reproductive technique.