recurrent miscarriage and implantation failure of unknown cause studied by a panel of thrombophilia conditions: increased frequency of fxiii val34leu polymorphism

Background: the role of acquired thrombophilia has been accepted as an etiology of recurrent miscarriage (rm); however, the contribution of specific inherited thrombophilic genes to this disorder has remained controversial. an increased incidence of rm has been suggested in women with inherited thrombophilia. methods: in this prospective study, assisted women with rm or repeated implant failure (rif) were subjected to thromboincode analysis, in order to identify 12 genetic variants for factor v leiden, factor v hong kong, factor v cambridge, fii, fxiii, fxii, and a1 carriers. patients included in this study were separated in rm cases (n=43), rif cases (n=36) and rif+rm (n=76). as a control group, patients undergoing ivf treatment (n=34) were used and a previously described 249 cases population as a representative sample of spanish population were selected. level of statistical significance was p<0.05 and groups were compared by fisher test, except for age that was compared by t-test. results: regarding fxiii, higher values were observed in rm (69.76%), rif (70%) and in rm+rif (68.42%) group when compared with our control group (52.94%) and general spanish population (56.5%), but these differences were statistically sig-nificant only in rif group (p=0.043, p=0.01). conclusion: concerning our findings, both rm and rif patients had a very similar panel of thrombophilia polymorphisms, suggesting that, in both, thrombophilia might have an important contribution. high frequency of val34leu polymorphism in rm/ rif presumably speaks in favor of a multifactorial rm genesis, wherean altered thrombophilia status plays a role.