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A Green and Efficient One-pot Synthesis of Propanamidesby a Three-component Reaction of 2-(2-oxopropyl) isoindoline-1,3-dione, Alkyl isocyanide and an E-cinnamic acid under Catalyst-free Conditions in Water
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نویسنده
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ramazani ali ,jafari ali ,joo sang woo ,ahmadi yavar ,sadri fariba ,azimzadeh asiabi pegah
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منبع
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journal of applied chemical research - 2016 - دوره : 10 - شماره : 4 - صفحه:33 -42
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چکیده
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A green and convenient protocol is described for the preparation of e-1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an e-cinnamic acid in water at room temperature. the methods used to follow the reactions are tlc and nmr, which indicated that there is no side product and the products were obtained without any purification. the structures of the products were deduced from their 1^h nmr, 13^c nmr and ir spectra. the present methodology offers several advantages such as a simple procedure, catalyst-free, mild reaction conditions, high yields, and the absence of any volatile and hazardous organic solvents.
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کلیدواژه
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2-(2-oxopropyl)isoindoline-1 ,3-dione ,Alkyl isocyanide ,E-cinnamic acid.
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آدرس
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university of zanjan, department of chemistry, ایران, university of zanjan, department of chemistry, ایران, yeungnam university, school of mechanical engineering, South Korea, nuclear science and technology research institute, north west reseach complex, ایران, payame noor university, department of chemistry, ایران, university of zanjan, department of chemistry, ایران
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پست الکترونیکی
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aliramazani@gmail.com
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Authors
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