A One-Pot Synthesis of Highly Functionalized Ketenimines by a Three-component 2-Thioxothiazolidin-4-one, Alkyl Isocyanides and Dialkyl Acetylenedicarboxylates

The 1:1 reactive intermediates produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates were trapped with 2-thioxothiazolidin-4-one to generate to highly functionalized ketenimines. a series of new 2-thioxothiazolidin-4-one derivatives were synthesized in moderate yields. the advantages of the present method include good functional group tolerance and simple experimental procedure and purification.