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Synthesis and Characterization of Novel 4-oxo-1, 4-dihydroquinoline-3-carboxamide Derivatives fromDiazomethane and HCl(g)
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نویسنده
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Nami Navabeh ,Kazemi Marziyeh
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منبع
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journal of applied chemical research - 2015 - دوره : 9 - شماره : 4 - صفحه:31 -40
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چکیده
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Reaction of thionyl chloride with 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 1 gave acid chloride 2. compound 2 was reacted with glycine and d-glutamic acid to afford 2-(7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carbonyl) aminopantandioicacid 3a and 2-(7-chloro-1-cyclopropyl-6-fluoro -4- oxo-1,4-dihydroquinoline-3-carbonyl)aminoaceticacid 3b. these compounds were changed to chloromethyl ketone derivatives 5a-b from diazomethane and then hcl (g) in dry diethyl ether.
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کلیدواژه
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Quinoline ,glycine ,D-glutamic acid ,Diazomethane ,Chloromethyl ketone
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آدرس
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Islamic Azad University, Qaemshahr Branch, Department of Chemistry, ایران, Islamic Azad University, Qaemshahr Branch, Department of Chemistry, ایران
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Authors
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