Synthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity

In the present work, a series of new n’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo-1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. the compound 5e was characterized by its elemental analysis, ir, 1hnmr and mass spectroscopy. the synthesized compounds (5a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.