preparation of novel thermo-sensitive polymer/βcd/ws2 nano-carriers for invitro drug release of tamoxifen in the presence and absence of near-infrared (nir) laser

In this work, two novel n-isopropylacrylamide (nipaa)/beta-cyclodextrin (β-cd)/ws2 and nipaa/n, ndimethyl acrylamide (dmaa)/ws2/βcd nanocarriers were prepared for in vitro tamoxifen drug release in the absence and presence of near-infrared (nir) laser. the characterization of resulting nanocarriers was carried out using x-ray diffraction (xrd), fourier transforms infrared spectroscopy (ftir), field-emission scanning  electron  microscopy  (fe-sem), and  thermogravimetric  analysis  (tga).  to  study  the  effect  of temperature on drug release for chemotherapy, tamoxifen drug release was comparatively evaluated at three different  temperatures  (25,  37, and  50°c)  with  ph  7.4  in  the  absence  of a nir  laser.  it  was  found  that tamoxifen release from  the  synthesized  nanocarriers at  50°c  was  significantly  greater than that  at  25  and 37°c. to investigate the effect of laser light on drug release for chemo-photothermal therapy, the in vitro release tests were carried out at 37°c with a nir laser light and with a power density of 1 w/cm2for 5 min. the  increase  of  tamoxifen  release  after a laser  light  was  29.8%  and  48.4%for  nipaa/βcd/ws2  and nipaa/dmaa/βcd/ws2 samples, respectively. thus, the combination of chemo/photothermal therapy had a  synergistic  effect  on  the  drug  release  of  tamoxifen.  furthermore,  the  total  drug  release  of nipaa/dmaa/βcd/ws2 was greater than that of nipaa/βcd/ws2 nanocarrier. furthermore, the kinetic release data were analyzed using zero-order, first-order, ritger-peppas, and higuchi models which followed the  zero-order  kinetic  release  model.  also,  good  stability  was  observed  for  tamoxifen  in  the  drug  release system.