application of n-isocyaniminotriphenyl phosphorane for preparation of heterocyclic acrylate as a key constituent of many industrial and pharmaceutical compounds

2-hydroxy  pyridine  undergoes  a  smooth  reaction  with  electron-deficient  acetylenic  esters  in  the presence  of  n-isocyaniminotriphenyl  phosphorane  under  reflux  conditions  to  produce  the heterocyclic  acrylate  compounds  in  high  yields.  the  acrylate  structures  with  e/z  isomers  were obtained  when  the  reaction  was  performed  with  4-hydroxy pyridine  and  4-hydroxy quinazoline, the  acrylate  structures  with  e/z  isomers  were obtained.  all  compounds  have many applications in medicinal  and  industrial  chemistry—configuration  of  e/z  isomers  distinguished  with  nuclear magnetic resonance technique and chemical shift of olefinic proton. the method offers a simple and efficient  route  for  preparing  acrylate  heterocyclic  compared  to  the  other  methodologies.  the structures of the products were deduced and supported by 1hnmr and ir spectroscopy.